Preparation of drug loaded gelatin microspheres and release behaviour in vitro

In this study,the aspirin loaded gelatin microspheres were prepared using aspirin as the drug model molecules.The SEM result showed that the surface structure of microspheres was more compact after drug loading.The drug loading property of microspheres was investigated,which showed that the drug loading property(drug loading capacity was 7.3% and encapsulation efficiency was 57.5%) was optimum as the aspirin dosage was 16 mg.The drug release properties of the gelatin microspheres in artificial body fluid were explored,good sustained release properties of gelatin microspheres were observed.And the release efficiency is much higher in the artificial gastric juice due to the larger presence of acid and pepsin,drug release rates in artificial gastric juice and artificial intestinal fluid were 28% and 40% respectively.The first order dynamic model could describe the release process in vitro perfectly.