Preparation of diclofenac sodium gelatin microspheres and its drug-release effect in Vitro and in Vivo

Objective To prepare diclofenac sodium gelatin microspheres and study the sustained-release effect.Methods Gelatin microspheres containing diclofenac sodium were prepared by simple coacervation technique and the drug release in vitro and vivo were tested.Results The diameter of the Gelatin microspheres was in the range of 48～100μm,and the average diameter was 70.70±11.29μm,and the drug loading was 35%.These studies indicated Gelatin microspheres had obviously sustained-release effect in vitro and vivo.Conclusion The studies showed that the purpose of sustained release was achieved