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Expression and Significance of CD105 in Giant Cell Tumor of Bone

Cai Ying

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Abstract

Objective To study the expression level of CD105 in giant cell tumor in the bone and detect the correlation between MVD counted with CD105 and the biological behavior of the tumor.Methods MVD in 38 cases of giant cell tumor in the bone were marked with CD105 by using SP immunohistochemical method. Results The average MVD in giant cell tumor of bone was 9.70±2.34.No significant difference was found among pathology gradeⅠ,Ⅱ and Ⅲ cases(P0.05),while there was significant difference between radiological grade Ⅲ and grade Ⅰcases(P0.05).Recurrent cases had higher MVD than in the cases without recurrence(P0.01).Conclusions MVD counted with CD105 is strongly related to its radiological grade and tumor recurrence.MVD marked by CD105 can be used as possible prognostic indication of tumor recurrence.

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What this paper is about

Objective To study the expression level of CD105 in giant cell tumor in the bone and detect the correlation between MVD counted with CD105 and the biological behavior of the tumor.Methods MVD in 38 cases of giant cell tumor in the bone were marked with CD105 by using SP immunohistochemical method. Results The average MVD in giant cell tumor of bone was 9.70±2.34.No significant difference was found among pathology gradeⅠ,Ⅱ and Ⅲ cases(P0.05),while there was significant difference between radiological grade Ⅲ and grade Ⅰcases(P0.05).Recurrent cases had higher MVD than in the cases without recurrence(P0.01).Conclusions MVD counted with CD105 is strongly related to its radiological grade and tumor recurrence.MVD marked by CD105 can be used as possible prognostic indication of tumor recurrence.

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Available abstract

Objective To study the expression level of CD105 in giant cell tumor in the bone and detect the correlation between MVD counted with CD105 and the biological behavior of the tumor.Methods MVD in 38 cases of giant cell tumor in the bone were marked with CD105 by using SP immunohistochemical method. Results The average MVD in giant cell tumor of bone was 9.70±2.34.No significant difference was found among pathology gradeⅠ,Ⅱ and Ⅲ cases(P0.05),while there was significant difference between radiological grade Ⅲ and grade Ⅰcases(P0.05).Recurrent cases had higher MVD than in the cases without recurrence(P0.01).Conclusions MVD counted with CD105 is strongly related to its radiological grade and tumor recurrence.MVD marked by CD105 can be used as possible prognostic indication of tumor recurrence.

Key concepts: Endoglin, Immunohistochemistry, Medicine, Giant-cell tumor of bone, Pathology, Significant difference, Radiological weapon, Giant cell

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Expression and Significance of CD105 in Giant Cell Tumor of Bone — Research Paper | ScholarLens