Diagnostic value of serum high-sensitivity C reactive protein for gout

Objective To observe the levels of high-sensitivity C reactive protein(hs-CRP) in the serum of gout patients with different clinical manifestation,and explore its diagnostic value.Methods 120 gout patients in our hospital from August 2009 to August 2011 were enrolled in this study.The patients were divided into acute exacerbation group(n=60) and intermittent group(n=60) according to the clinical manifestation.Fifty healthy volunteers were enrolled in this study as the control group.There was no statistically significant difference at age and sex between the three groups(χ2=3.314,2.485;P0.05).3 ml venous bloods were extracted in all the individuals in order to detect the level of serum hs-CRP by bead enhanced immunoturbidimetric assay.Results The levels of hs-CRP in acute exacerbation group,intermittent group and the control group were(8.84±1.78) mg/L,(3.26±1.25) mg/L,(0.91±0.24) mg/L,respectively.The level of hs-CRP in acute exacerbation group was significantly higher than that in the other two groups(t=2.700,2.595;P=0.011,0.014),and the level of hs-CRP in intermittent group was significantly higher than that in the control group(t=2.153,P=0.040).Conclusion The gout patients with different clinical manifestation have different levels of hs-CRP.Determination of serum hs-CRP is helpful for the diagnosis of gout.