Diagnostic Value of Serum Atrial Natriuretic Peptide in Patients With Diastolic Heart Failure

Objective: To investigate the diagnostic value of serum level of atrial natriuretic peptide ( ANP) in patients with diastolic heart failure ( DHF) . Methods: Sixty-six patients with DHF were selected as experimental group,64 patients with dyspnea but without DHF as control group. Levels of ANP and brain natriuretic peptide ( BNP) were detected by enzyme linked immunosorbent assay ( ELISA) . Ultrasonic cardiac examination was made as well. Results: Serum levels of ANP in patients with DHF were significantly higher than that without DHF ( P 0. 05) . There was statistical significance when it was considered that ANP was higher than normal or double or triple than normal value as a criteria of diagnosis of DHF ( P 0. 05) . Combined determination of serum levels of ANP and BNP would help to increase the diagnostic value for DHF. Conclusions: Serum level of ANP is a good predictor for diagnosis of DHF. Combined detection of serum levels of ANP and BNP will help to increase the accuracy for diagnosis.