The concentration of S-100b in blood and CSF of patients with viral encephalitis and its clinical significance

Objective To investigate the changes of S-100b protein concentration in serum and cerebrospinal fluid from patients with viral encephalitis and to find out the correlation with anomaly electroencephalogram and low density focus volume of imageology. Methods Fourty-two cases with viral encephalitis were collected as observe group and 25 cases health examinater or patients with operation of appendix or cholecyst were collected as control group. S-100b protein of cerebrospinal fluid and serum was detected by enzyme-linked immunosorbent assay of di-antibody with filling. Comparison analyse was performed by SPSS10.0 statistical package. Results Patients with acute viral encephalitis has a significantly higher concentration of S-100b protein of blood and cerebrospinal fluid(P0.01) than recoverys and control group in the release of S-100b protein of blood and cerebrospinal fluid in patients with acute viral encephalitis was associated with the low density focus volume of imageology(r_ CSF= 0.756, P0.01; r_ blood=0.685, P0.01). Concentration of S-100b protein of cerebrospinal fluid is significantly higher than that of blood in patients with light, midrange and weight anomaly electroencephalogram (P 0.01). [WT5”HZ]Conclusion The concentration of S-100b protein of blood and cerebrospinal fluid in patients with acute viral encephalitis indicates the severity of the disease or the extent of lesion of nueroglial cell. It is a useful biochemical marker of brain-tissue damage.