The value of S-100 b protein in children with viral encephalitis in determining state of illness and in evaluating prognosis

Objective To investigate cerebrospinal fluid and serum S-100 b protein levels in children with viral encephalitis to discuss their values in determining state of illness and in evaluating prognosis.Methods 46 cases with viral encephalitis were collected as observe group and 20 cases patients with operation were collected as control group.46 children with viral encephalitis were divided into two groups according to the severity of disease: coma group(15 cases) and non-coma group(31 cases).The double-antibodies sandwich ELISA was used to detect S-100 b protein concentrations in CSF and serum in these 46 patients and 20 controls.Results ①CSF and serum S-100b level of observed group were higher than control group(P0.01).② CSF and serum S-100 b level of coma group were higher than those in non-coma group(P0.01).③patients with acute viral encephalitis has a significantly higher concentration of S-100 b protein of CSF and serum than recovery(P0.01).④CSF S-100 b correlated with their serum concentrations(r=0.746,P=0.05).Conclusion The concentration of S-100b protein of CSF and serum in patients with acute viral encephalitis is relative with brain-tissue damage of viral encephalitis.There are important clinical values in determining state of illness and in evaluating prognosis.