2009•Acta Academiae Medicinae JiangxiRequires access
The Relationships Between Expression of COX-2,Microvessel Density and the Prognosis of Endometrial Carcinoma
Xiong Shu-hua
Open publisher page 1 citations
Abstract
Objective To explore the relationships between expression of COX-2,MVD and the prognosis of patients with endometrial carcinoma.Methods COX-2 expression in endometrial carcinoma tissue were detected by SP immunohistochemical method in 60 patients.The relationships between COX-2 expression,MVD and prognosis were analyzed.Results Kaplan-Meier survival analysis showed that survival rate in patients with COX-2 positive was significantly lower than that with COX-2 negative(P0.05);survival rate in patients with MVD≥35 was significantly lower than that with with MVD35(P0.05).COX regression analysis showed that COX-2,MVD,Histological differentiation,oporation stage metastasis of lymphnode,myometrial invation were the independent prognostic factors for endometrial carcinoma.Conclusion High expression of COX-2 and high level of MVD are associated with poor survival of patients with endometrial carcinoma.COX-2 and MVD are one of independent prognostic factors for endometrial carcinoma.