Correlation of expression of VEGF-C with LVD in human colon carcinoma

Objective To investigate the Correlation of expression of vascular endothelial growth factor(VEGF)-C with the human lymphatic vessel endothelial(LVD) in human colon carcinoma.Methods The expressions of VEGF-C and hyaluron receptor-1(LYVE-1) were detected in 60 cases of colon cancer,10 cases of colon adenoma and normal colon tissues of 10 patients with Envitision-2 immunohistochemical method.The correlation between VEGF-C expression and LVD in colon cancer was studied.Results The positive expression rate of VEGF-C was 53.33% in colon cancer,which was negative in normal colon tissues and colon adenoma.The positive expression of VEGF-C in colon carcinoma tissues was maily in the cell plasma,which was displayed as yellow pellet.The positive expression rate of LYVE-1 was 76.67% in colon cancer,which was significantly higher than 50% in colon adenoma(P0.01).The LVD in colon cancer was 5.761±1.676,which was significantly higher than 1.722±0.390 in colon adenoma(P0.01).VEGF-C expression had a positive correlation with LVD(P0.05).Conclusion The expressive rate of VEGF-C in colon cancer is significantly higher than that in benign tumor.VEGF-C expression is positively correlated with LVD.