Expressions of Id-1 and VEGF in colon carcinoma and their clinical significance

Objective To explore the expressions of inhibitor of differentiation-1 ( Id-1) and vascular endothelial growth factor ( VEGF) in colon carcinoma and their clinical significance. Methods Immunohistochemistry SP technique was applied to analyzing the expressions of Id-1 and VEGF in 94 cases of colon carcinoma tissues and 46 cases of normal colon tis- sues. Results The expression rates of Id-1 and VEGF in colon carcinoma tissues were significantly higher than those in nor- mal colon tissues ( 67. 0% vs 10. 9% ,P 0. 01; 69. 1% vs 17. 4% ,P 0. 01) . The expression of Id-1 in colon carcinoma was correlated with grade of differentiation,infiltration depth,lymph node metastasis and TNM stages ( all P 0. 01) ,but not cor- related with age,sex and tumor size ( all P 0. 05) . The expression of VEGF in colon carcinoma was correlated with lymph node metastasis and TNM stages ( all P 0. 01) ,but not correlated with age,sex,grade of differentiation,tumor size and infil- tration depth ( all P 0. 05) . The expression of Id-1 was positively related to expression of VEGF in colon carcinoma tissues ( r = 0. 413,P 0. 01) . Conclusions The over-expressions of Id-1 and VEGF are closely related to the invasion and metastasis of colon carcinoma,and they may be together involved in the progression of colon carcinoma and angiogenesis. Id-1 and VEGF may be served as the markers for judging the malignant degree and the prognosis of colon carcinoma.