Analysis on clinical features and curative effect in patients with neuropsychiaric systemic lupus erythematosus

Objective To explore the clinical features and treatment effect in patients with neuropsychiaric systemic lupus erythematosus.Methods The retrospective analysis about clinical manifestations,a number of immunological indicators,complications and with complications and treatment were carried out in 60 cases with neuropsychiaric systemic lupus erythematosus(NPSLE).Resluts The highest incidence was seizures(28.3%) among the clinical manifestations of neuropsychiatric lupus;this was followed by lupus headache(23.3%),disturbance of consciousness(18.3%).The number of complications and with complications in NPSLE group(85%) was higher than that of in non-NPSLE group(32%),the proportion of the highest is lupus nephritis(58%).Compared the other immunologic parameters,there was no significant difference between the two groups.The remission rate in methylprednisolone and cyclophsphamide pulse therapy group(80%) was higher than that of in methylprednisolone pulse therapy group(51%).Conclusion Neuropsychiatric lupus clinical manifestations are varied incude seizures,lupus headache and disturbance of consciousness.Complications and with complications can occur in patients with systemic lupus erythematosus prompted neuropsychiaric lupus increase the probability.The therapy effective of hormone and immunosuppressant is much better.