24-Hour Blood Pressure Control by Once-daily Administration of Losartan Assessed by Ambulatory Blood Pressure Monitoring

OBJECTIVE: To assess 24h ambulatory blood pressure lowerings and tolerability after weeks of therapy with losartan 50-100mg once daily. METHOD: After 1-week wash-out and 2-weeks placebo run-in, patients with seated diastolic blood pressure (SeDBP) 95-115mmHg and ambulatory diastolic blood pressure ≥ 85 mmHg were investigated by openlabel method with losartan 50mg treatment for 4 weeks, followed by dose titration to 100mg once-daily for another 4 weeks in those patients with SeDBP≥90mmHg. Ambulatory blood pressure monitoring (ABPM) was performed over 24-hour period after placebo run-in and at the end of weeks. RESULTS:Mean reductions from baseline in 24h, day -time (6:00-22:00), night-time (22:00-6:00) were (11.0 ?9.5/6.8 ?5.8),(11.5 ?10.8/7.0 ?6.2),(10.2 ?9.5/6.6 ? 7.0) mmHg. Trough: peak ratios were 75.5% for DBP and 74.5% for SBP. The frequency of adverse events was very low, and no cough happened. CONCLUSION: losartan 50- 100mg given once daily appears to be a well-tolerated, safe,and effective antihypertensive treatment.