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2007•Journal of Regional Anatomy and Operative SurgeryRequires access

Expressions of bone morphogenetic proteins-9 in liver tissue of type 2 diabetic rats

Wei Chen

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Abstract

Objective To study changes of bone morphogenetic proteins(BMP)-9 gene transcription and protein expression in liver of type 2 diabetic rats.Methods Totally 20 Wistar rats were selected and randomly devided into type 2 diabetic model group and normal control group.Rats were killed at corresponding time point,and then BMP-9 gene transcription and protein expression in liver were detected by RT-PCR and Western-blot analysis.Results BMP-9 gene transcription and protein expression in type 2 diabetic model group were significantly lower than that in the normal control group(P0.05).Conclusion The BMP-9 gene transcription and protein expression in liver of type 2 diabetic rats are significantly lower.These changes may be associated with the production and progression of type 2 diabetes mellitus.

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What this paper is about

Objective To study changes of bone morphogenetic proteins(BMP)-9 gene transcription and protein expression in liver of type 2 diabetic rats.Methods Totally 20 Wistar rats were selected and randomly devided into type 2 diabetic model group and normal control group.Rats were killed at corresponding time point,and then BMP-9 gene transcription and protein expression in liver were detected by RT-PCR and Western-blot analysis.Results BMP-9 gene transcription and protein expression in type 2 diabetic model group were significantly lower than that in the normal control group(P0.05).Conclusion The BMP-9 gene transcription and protein expression in liver of type 2 diabetic rats are significantly lower.These changes may be associated with the production and progression of type 2 diabetes mellitus.

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Available abstract

Objective To study changes of bone morphogenetic proteins(BMP)-9 gene transcription and protein expression in liver of type 2 diabetic rats.Methods Totally 20 Wistar rats were selected and randomly devided into type 2 diabetic model group and normal control group.Rats were killed at corresponding time point,and then BMP-9 gene transcription and protein expression in liver were detected by RT-PCR and Western-blot analysis.Results BMP-9 gene transcription and protein expression in type 2 diabetic model group were significantly lower than that in the normal control group(P0.05).Conclusion The BMP-9 gene transcription and protein expression in liver of type 2 diabetic rats are significantly lower.These changes may be associated with the production and progression of type 2 diabetes mellitus.

Key concepts: Medicine, Bone morphogenetic protein, Endocrinology, Western blot, Internal medicine, Transcription (linguistics), Gene expression, Gene

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