2007•Journal of Practical Diagnosis and TherapyRequires access

Clinical observation on the effects of mifepristone and GnRH-a for postoperative pelvic endometriosis

Shang Yanhon

Abstract

Objective To study the effects and safety of mifepristone and GnRH-a for postoperative pelvic endometriosis.Methods Eighty-three pelvic endometriosis cases were analyzed retrospectively,in which 41 were given mifepristone(mifepristone group),15 were given gestrinone(gestrinone group) and other 27 cases didn't take any drugs(control group).Recurrence rate and adverse effect rate were compared among these groups.Results The recurrence rates of mifepristone group and GnRH-a group were 13.3% and 17.1%,respectively,significantly lower than that of control group(P0.05,P0.05).The adverse effect rate of mifepristone group was 14.6%,which was significantly lower than that of gestrinone group(66.7%)(P0.05).Conclusion Mifepristone and gestrinone are effective for postoperative pelvis endometriosis.Mifepristone has less adverse effects than that of gestrinone.

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Key concepts: Mifepristone, Medicine, Endometriosis, Adverse effect, Urology, Gynecology, Internal medicine, Pregnancy