The Optimal Compatibility Dosage of Sufentanil-Morphine Combination with Epidural Postoperative Analgesia

Objective: To observe the postoperative analgesic effect and adverse effects with different doses of sufentanil and mor-phine combination in patients undergoing abdominal hysterectomy surgery and find out the optimal compatibility dosage.Methods: Ninety ASAⅠ-Ⅱpatients aged 20-60 years,undergoing the abdominal hysterectomy surgery were randomly divided into three groups,30 in each.All patients received combined spinal and epidural anesthesia.In groupⅠpatients received sufentanil 10μg and morphine 2 mg plus droperidol 1 mg and 1 % ropivacaine 20 mg;In group Ⅱ patients received sufentanil 15μg and morphine 1.5 mg plus droperidol 1 mg and 1 % ropivacaine 20 mg and in group Ⅲ patients were given sufentanil 20μg and morphine 1 mg plus droperidol 1 mg and 1 % ropi-vacaine 20 mg.Postoperative pain was recorded at 2 h,4 h,6 h,8 h,12 h,18 h and 24 h after operation.Postoperative analgesic effects were estimated by Visual Analogue Scale(VAS).Additional analgesics and adverse effects such as sedation,nausea and vomiting were recorded in the first postoperative 24 h.Results: The VAS scores at hours 2,4,6,8,12,18,24 after operation were significantly lower in group Ⅱ(P0.05) and VAS scores at postoperative time 2 h,4 h,6 h were significantly lower in group Ⅲ than group Ⅰ(P0.05).There were no differences in additional analgesics using and the incidence of sedation in the three groups but comparing with patients in group Ⅲ,patients in group Ⅰ and group Ⅱ had lower incidence of nausea and vomiting(P0.05).Conclusion: Receiving epidural sufentanil 15μg and morphine 1.5 mg can provide stable and satisfying postoperative analgesia in patients undergoing the abdominal hysterectomy surgery.Otherwise the dose of sufentanil-morphine combination has lower incidence of adverse effects.