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2008•Guangxi Medical JournalRequires access

Effect of EGCG on proliferation of prostate cancer PC-3 cells

MO Fang-rong

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Abstract

Objective To investigate the effect of Epigallocatechin-3-gallate(EGCG)on growth inhibition and cell cycle of the prostate cancer PC-3 cells.Methods The cytotoxic,antiproliferative and cell cycle arrest effects of EGCG on PC-3 cells were determined with varying concentration of EGCG treatment for 24 hours by MTT assay and flow cytometry.Results In comparison to the control,all the 3 different concentration of EGCG was able to inhibit the growth of malignancy cell lines and increase the cell number in G0～G1 phase.Conclusion EGCG can inhibit the proliferation of PC-3 cell by inducing the G0～G1 phase arrest.

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What this paper is about

Objective To investigate the effect of Epigallocatechin-3-gallate(EGCG)on growth inhibition and cell cycle of the prostate cancer PC-3 cells.Methods The cytotoxic,antiproliferative and cell cycle arrest effects of EGCG on PC-3 cells were determined with varying concentration of EGCG treatment for 24 hours by MTT assay and flow cytometry.Results In comparison to the control,all the 3 different concentration of EGCG was able to inhibit the growth of malignancy cell lines and increase the cell number in G0～G1 phase.Conclusion EGCG can inhibit the proliferation of PC-3 cell by inducing the G0～G1 phase arrest.

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Available abstract

Objective To investigate the effect of Epigallocatechin-3-gallate(EGCG)on growth inhibition and cell cycle of the prostate cancer PC-3 cells.Methods The cytotoxic,antiproliferative and cell cycle arrest effects of EGCG on PC-3 cells were determined with varying concentration of EGCG treatment for 24 hours by MTT assay and flow cytometry.Results In comparison to the control,all the 3 different concentration of EGCG was able to inhibit the growth of malignancy cell lines and increase the cell number in G0～G1 phase.Conclusion EGCG can inhibit the proliferation of PC-3 cell by inducing the G0～G1 phase arrest.

Key concepts: Cell cycle, Flow cytometry, Cell growth, MTT assay, Chemistry, Prostate cancer, Cancer research, Cell cycle checkpoint

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