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2010•Wuhan Daxue xuebao. Yixue banRequires access

Inhibitive Effects of EGCG on the Proliferation of Human Prostate Cancer Cell Line PC-3

Zhiwei Yang

Open publisher page 2 citations

Abstract

Objective: To study the inhibitive effect of(-)-epigallocatechin gallate(EGCG) on the proliferation and cell cycle of human prostate cancer cells in vitro.Methods: The morphological alterations of PC-3 cells treated by EGCG were observed under inverse microscopy.The cell proliferation was assayed by MTT method,and the cell cycle changes were observed by flowcytometry.Results: After being treated with EGCG,PC-3 cells were round and small,and grew against the wall under inverse microscope.In comparison to the control,all the different concentrations of EGCG were able to inhibit the growth of malignancy cell lines,and the inhibition of proliferation of PC-3 cells increased in a time-and dose-dependent manner(P0.05).Furthermore,the cell cycle of PC-3 cells treated by EGCG was arrested in the G0/G1 phase in a dose-dependent manner.Conclusion: That EGCG has significantly inhibitory effect on the PC-3 cells in vitro through arresting the cell cycle.

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Objective: To study the inhibitive effect of(-)-epigallocatechin gallate(EGCG) on the proliferation and cell cycle of human prostate cancer cells in vitro.Methods: The morphological alterations of PC-3 cells treated by EGCG were observed under inverse microscopy.The cell proliferation was assayed by MTT method,and the cell cycle changes were observed by flowcytometry.Results: After being treated with EGCG,PC-3 cells were round and small,and grew against the wall under inverse microscope.In comparison to the control,all the different concentrations of EGCG were able to inhibit the growth of malignancy cell lines,and the inhibition of proliferation of PC-3 cells increased in a time-and dose-dependent manner(P0.05).Furthermore,the cell cycle of PC-3 cells treated by EGCG was arrested in the G0/G1 phase in a dose-dependent manner.Conclusion: That EGCG has significantly inhibitory effect on the PC-3 cells in vitro through arresting the cell cycle.

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Available abstract

Objective: To study the inhibitive effect of(-)-epigallocatechin gallate(EGCG) on the proliferation and cell cycle of human prostate cancer cells in vitro.Methods: The morphological alterations of PC-3 cells treated by EGCG were observed under inverse microscopy.The cell proliferation was assayed by MTT method,and the cell cycle changes were observed by flowcytometry.Results: After being treated with EGCG,PC-3 cells were round and small,and grew against the wall under inverse microscope.In comparison to the control,all the different concentrations of EGCG were able to inhibit the growth of malignancy cell lines,and the inhibition of proliferation of PC-3 cells increased in a time-and dose-dependent manner(P0.05).Furthermore,the cell cycle of PC-3 cells treated by EGCG was arrested in the G0/G1 phase in a dose-dependent manner.Conclusion: That EGCG has significantly inhibitory effect on the PC-3 cells in vitro through arresting the cell cycle.

Key concepts: Cell cycle, Cell growth, In vitro, Cell culture, Cell, Chemistry, MTT assay, Cancer cell

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