Expression of inhibitors of DNA binding-1 in the endometrial adenocarcinoma and its correlation with ERα

Objective To study the expression of inhibitors of DNA binding-1(Id-1) in endometrial adenocarcinoma and its correlation with ERα.Methods Id-1 and ERα proteins were analyzed using immunohistochemistry in 56 patients with endometrial adenocarcinoma,20 patients with normal endometria and 18 patients with atypia hyperplasia.Results The level of Id-1 expression was found in an increased order,while ERα was decreased from normal endometria to atypia hyperplasia,and then to endometrial adenocarcinoma(all P0.05).The expression of Id-1 was significantly correlated with the histological grade,clinica1 stage and depth of myometrial invasion(P0.05).ERα expression was significantly correlated with the depth of myometrial invasion(P0.05).There was no association between the expression of Id-1 and survival time(P0.05).Id-1 expression was positively correlated with ERα in endometrial adenocarcinomas(r=0.284,P=0.034).Conclusions The expression of Id-1 is up-regulated in endometrial adenocarcinoma,and Id-1 coexpression with ERαmay take part in the progression of endometrial adenocarcinoma.