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Comparaitive study of the content of plasma atrial natrinretic peptides(ANP),endothelin-1(ET-1) in patients with diabetic nephropathy

Cai Xu

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Abstract

Objective To investigate changes in plasma atrial natrinretic peptides(ANP),endothelin-1(ET-1),before and after treatment in patients with diabetic nephropathy(DN).Methods The content of plasma ANP and ET-1 were measured in 43 DN cases and 20 normal control cases using radioimmunoassary.Results The plasma levels of ET-1 and ANP were significantly increased in the patients with DN compared with those in the controls(P0.05).The plasma levels of ET-1 and ANP after treatment were significantly lower than that before therapy.The plasma levels of ET-1 and ANP in treatment group were lower than those in routine group after treatment for 12 months(P0.05).Conclusion The plasma levels of ET-1 and ANP may be related with diabetic nephropathy.

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What this paper is about

Objective To investigate changes in plasma atrial natrinretic peptides(ANP),endothelin-1(ET-1),before and after treatment in patients with diabetic nephropathy(DN).Methods The content of plasma ANP and ET-1 were measured in 43 DN cases and 20 normal control cases using radioimmunoassary.Results The plasma levels of ET-1 and ANP were significantly increased in the patients with DN compared with those in the controls(P0.05).The plasma levels of ET-1 and ANP after treatment were significantly lower than that before therapy.The plasma levels of ET-1 and ANP in treatment group were lower than those in routine group after treatment for 12 months(P0.05).Conclusion The plasma levels of ET-1 and ANP may be related with diabetic nephropathy.

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Available abstract

Objective To investigate changes in plasma atrial natrinretic peptides(ANP),endothelin-1(ET-1),before and after treatment in patients with diabetic nephropathy(DN).Methods The content of plasma ANP and ET-1 were measured in 43 DN cases and 20 normal control cases using radioimmunoassary.Results The plasma levels of ET-1 and ANP were significantly increased in the patients with DN compared with those in the controls(P0.05).The plasma levels of ET-1 and ANP after treatment were significantly lower than that before therapy.The plasma levels of ET-1 and ANP in treatment group were lower than those in routine group after treatment for 12 months(P0.05).Conclusion The plasma levels of ET-1 and ANP may be related with diabetic nephropathy.

Key concepts: Medicine, Endothelin receptor, Internal medicine, Atrial natriuretic peptide, Endocrinology, Nephropathy, Diabetic nephropathy, Endothelin 1

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Comparaitive study of the content of plasma atrial natrinretic peptides(ANP),endothelin-1(ET-1) in patients with diabetic nephropathy — Research Paper | ScholarLens