Effect of atorvastatin on content of plasma atrial natrinretic peptides and endothelin-1 in patients with diabetic nephropathy

Objective:To investigate the effect of atorvastatin on content of plasma atrial natrinretic peptides and endothelin-1 in patients with diabetic nephropathy (DN).Methods:The 40 DN patients were average divided into atorvastatin treat group,and routine treat group.Another 20 normal persons were regard as normal control group.The contents of plasma ANP and ET-1 were measured using radioimmunoassary in all subject and treat before and after.Results:The plasma levels of ET-1 and ANP significantly increased in DN patients compared with those in the normal control group (P0.01).After treatment,the plasma levels of ET-1 [(176±37) ng/L vs.(246±20) ng/L]and ANP[(56±18) ng/L vs.( 102±22) ng/L] significantly lower (P0.01)than those before therapy in atorvastatin treat group.The plasma levels of ET-1 and ANP in atorvastatin treat group were lower [(218±22) ng/L,( 68±28 ) ng/L] than those in routine treat group after treatment for 6 months (P0.01).Conclusion:Atorvastatin can decrease the plasma levels of ET-1 and ANP,and improve endothelial function in patients with diabetic nephropathy.