VISFATIN G-948T POLYMORPHISM IN EGYPTIAN TYPE2 DIABETES

Visfatin is a newly discovered adipokine found in abundance in visceral fat. It lowers plasma glucose in human and mice. In this study, we investigated the role of genetic variant (G - 948 T) of visfatin on serum visfatin and biochemical markers in type 2 diabetic patients. In a case control study 40 diabetic obese type2 compared to 20 healthy controls age and sex matched. Laboratory and anthropometric measurements were included fasting blood glucose, HbA1C, lipid profile, serum visfatin serum insulin, Body Mass Index (BMI), waist hip ratio. Visfatin G - 948Tgene polymorphism was performed using the real-time PCR method. Our results showed significant correlation between visfatin BMI, waist, WH ratio, fasting glucose, fasting insulin, HOMAIR, cholesterol, triglycerides, LDL but negative correlation with HDL in obese diabetics. G-allele had higher BMI, fasting blood glucose, cholesterol, triglyceride, HOMAIR, fasting insulin than T-allele carrier however not statistically significant. In conclusion: Variants of visfatin allele might be responsible for changes in visfatin expression and biochemical markers in unrelated Egyptian type 2 diabetic obese patients, visfatin G-948T polymorphism G allele may account for the development of insulin resistance. (Journal of American Science 2010;6(10):509-514). (ISSN: 1545-1003).