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Simvastatin inhibits migration of nasopharyngeal carcinoma-2(CNE2) cells

Liu Xiao-ai

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Abstract

AIM: To study the effect of simvastatin on cells migration of nasopharyngeal carcinoma cell line CNE2 in vitro.METHODS: The depressive effects of simvastatin on CNE2 cells migration were observed by scratch wound healing assay and transwell migration assay.RESULTS: The experimental result of scratch wound healing assay showed that simvastatin inhibited migration of nasopharyngeal carcinoma CNE2 cells in a time-and dose-dependent manner.With 2.5 μmol/L simvastatin treatment for 24 hs,the migration lenth was 50.1% of that in control group.Transwell experimental result indicated that with 2.5 μmol/L simvastatin treatment for 24 hs,the migrating cell population was 69.2% of that in control group.CONCLUSION: Simvastatin can inhibits CNE2 cells migration in a time-and dose-dependent manner,which can provide rational clues for clinical research of simvastatin.

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What this paper is about

AIM: To study the effect of simvastatin on cells migration of nasopharyngeal carcinoma cell line CNE2 in vitro.METHODS: The depressive effects of simvastatin on CNE2 cells migration were observed by scratch wound healing assay and transwell migration assay.RESULTS: The experimental result of scratch wound healing assay showed that simvastatin inhibited migration of nasopharyngeal carcinoma CNE2 cells in a time-and dose-dependent manner.With 2.5 μmol/L simvastatin treatment for 24 hs,the migration lenth was 50.1% of that in control group.Transwell experimental result indicated that with 2.5 μmol/L simvastatin treatment for 24 hs,the migrating cell population was 69.2% of that in control group.CONCLUSION: Simvastatin can inhibits CNE2 cells migration in a time-and dose-dependent manner,which can provide rational clues for clinical research of simvastatin.

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Available abstract

AIM: To study the effect of simvastatin on cells migration of nasopharyngeal carcinoma cell line CNE2 in vitro.METHODS: The depressive effects of simvastatin on CNE2 cells migration were observed by scratch wound healing assay and transwell migration assay.RESULTS: The experimental result of scratch wound healing assay showed that simvastatin inhibited migration of nasopharyngeal carcinoma CNE2 cells in a time-and dose-dependent manner.With 2.5 μmol/L simvastatin treatment for 24 hs,the migration lenth was 50.1% of that in control group.Transwell experimental result indicated that with 2.5 μmol/L simvastatin treatment for 24 hs,the migrating cell population was 69.2% of that in control group.CONCLUSION: Simvastatin can inhibits CNE2 cells migration in a time-and dose-dependent manner,which can provide rational clues for clinical research of simvastatin.

Key concepts: Simvastatin, Nasopharyngeal carcinoma, Cell migration, Population, In vitro, Wound healing, Cell culture, Pharmacology

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