The effects of domestic irbesartan on blood pressure and renal function in the primary hypertension

Objective To evaluate the effects of domestic irbesartan on blood pressure and renal function in the aged with primary hypertension.Methods Renal function plasma and urine β2 microglobulin(β2-MG)were measured and blood pressure was investigated by 24-hour ambulatory blood monitoring in 60 primary hypertension who received domestic irbesartan(150mg/d,followed up every 1～2 weeks.If the effect was not ideal,the dose could be added to 300 mg/d)in 8-week's treatment.Results After the treatment,24 hours mean systolic blood pressure,24-hour mean diastolic blood pressure,mean day systolic blood pressure,mean day diastolic blood pressure,mean night systolic blood pressure,mean night diastolic blood pressure were significantly reduced(P0.05 or P0.01),At the same time.domestic irbesartan induced a remarkable reduction of plasma and urine(β2-MG).Conclusion The antihypertensive effects of domestic irbesartan can persist for 24 hours and can reduce urinary protein.