Study on Multi-slice CT Perfusion of Hemodynamic Change of the Primary Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Purpose To study on multi-slice CT perfusion(MSCTP) of hemodynamic change of the primary hepatocellular carcinoma(HCC) with portal vein tumor thrombus(PVTT).Methods MSCT perfusion imaging was performed with a spiral CT scanner(GE Lightspeed 16 Slice) in total 84 patients and analyzed with perfusion 3 software package.Liver perfusion maps werc calculated by means of the tracer kinetic model.The weighted sum-mation of the aortic and portal venous curve were de-convolved against the liver parenchymal curve to derive functional parameters such as total hepatic blood flow(HBF),hepatic blood volume(HBV),mean transit time(MTT),permeability of capillary vessel surface(PS) and hepatic arterial fraction(HAF) were calculated,and the change of the hemodynamic was estimated.Results Compared with the positive control group B,the HBF and HAF of the tumor in test group A increased significantly,and so the HBV and HAF of the PVTT in test group A(P0.05).However,the MTT of the tumor in test group A was shorter than that of the positive control group B significantly(P 0.05).Compared with the negative control group C,the HBF,HBV and HAF of the hyperperfusion abnormality in test group A increased significantly.Conclusion MSCTP parameters may reflect the features of blood perfusion,and to evaluate the hemodynamic change of HCC with PVTT.