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2007•Zhonghua zhongyiyao zazhiRequires access

HPLC determination of ursolic acid in Kangzhitong Jiangzhi Capsule

Chen Li

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Abstract

Objective: To establish a method for HPLC determination of ursolic acid in Kangzhitong Jiangzhi Capsule.Methods: HPLC,chromatographic column Kromasil C18(4.6mm×250 mm,5μm)and the mobile phase consisted of methyl alcoholwater-ammonium acetate-acetonitrile(9∶25∶0.8∶65) were used to find ursolic acid.The flow rate was 1.0ml·min and the detector wave-length was set at 215nm.Results: The calibration curve was in good linearity over the range of 64-320μg/ml(r=0.9996).The average recovery rate was 100.10%,with RSD=1.32%.Conclusion: This method is simple,accurate and reproducible so it can be used to determine the content of ursolic acid in Kangzhitong Jiangzhi Capsule.

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What this paper is about

Objective: To establish a method for HPLC determination of ursolic acid in Kangzhitong Jiangzhi Capsule.Methods: HPLC,chromatographic column Kromasil C18(4.6mm×250 mm,5μm)and the mobile phase consisted of methyl alcoholwater-ammonium acetate-acetonitrile(9∶25∶0.8∶65) were used to find ursolic acid.The flow rate was 1.0ml·min and the detector wave-length was set at 215nm.Results: The calibration curve was in good linearity over the range of 64-320μg/ml(r=0.9996).The average recovery rate was 100.10%,with RSD=1.32%.Conclusion: This method is simple,accurate and reproducible so it can be used to determine the content of ursolic acid in Kangzhitong Jiangzhi Capsule.

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Available abstract

Objective: To establish a method for HPLC determination of ursolic acid in Kangzhitong Jiangzhi Capsule.Methods: HPLC,chromatographic column Kromasil C18(4.6mm×250 mm,5μm)and the mobile phase consisted of methyl alcoholwater-ammonium acetate-acetonitrile(9∶25∶0.8∶65) were used to find ursolic acid.The flow rate was 1.0ml·min and the detector wave-length was set at 215nm.Results: The calibration curve was in good linearity over the range of 64-320μg/ml(r=0.9996).The average recovery rate was 100.10%,with RSD=1.32%.Conclusion: This method is simple,accurate and reproducible so it can be used to determine the content of ursolic acid in Kangzhitong Jiangzhi Capsule.

Key concepts: Ursolic acid, Capsule, Chromatography, High-performance liquid chromatography, Chemistry, Calibration curve, Ammonium acetate, Recovery rate

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