In-Vitro and In-Vivo Inhibitory Effect of Compound Ganduqing on Hepatitis B Virus

[Objective] To observe the in-vitro and in-vivo inhibitory effect of compound Ganduqing, a Chinese herbal prescription, on hepatitis B virus (HBV). [Methods] Duck models of congenital infection of HBV was used in the invivo test and the dynamic changes of serum duck HBV DNA titer was observed. 2.2.15 cell line was applied in the invitro test and the inhibitory effect of Ganduqing on HBsAg and HBeAg was evaluated. [Results] In the in-vivo test, serum duck HBV DNA titer was obviously decreased after 10 days of administration (P0.01) and began to rebound after 3 days of suspension but still lower than that in model group (P0.01). In the in-vitro test, the therapeutic index (the ratio of 50% toxic concentration and 50% inhibitory concentration) of Ganduqing was 66.81 for HBsAg and 34.18 for HBeAg. [Conclusion] Compound Ganduqing exerts a certain in-vitro and in-vivo inhibitory effect on HBV.