Protective Effects of Gankangle against Acute Hepatic Injury in Mice

Objective To study the effects of Gankangle,a traditional Chinese prescription for hepatopathy,against acute hepatic injury in mice and to explore its mechanism.Methods Mouse Models of acute hepatic injury were induced by intraperitoneal injection of carbon tetrachloride and thioacetamide(TAA),separately.Meanwhile,those mice were treated by intragastric administration of Gankangle.The serum levels of alanine aminotransferase(ALT) and aspartate aminotransferase(AST),the content of malondialdehyde(MDA) in the liver,and hepatic index were measured.Results Gankangle could significantly decrease the serum levels of ALT and AST,the content of MDA,and the hepatic index in mice with hepatic injury.Conclusion Gankangle has protective effects against acute hepatic injury in mice.