Distribution and drug resistance of pathogenic bacteria causing lower respiratory tract infections in children

OBJECTIVE To understand the distribution and drug resistance of pathogenic bacteria from sputum culture of the children with lower respiratory tract infections so as to guide the clinical treatment of the lower respiratory tract infections.METHODS The clinical data of 516cases of hospitalized children with lower respiratory tract infections from Jan 2011to Oct 2012were collected,sputum were identified by ATB bacterium identification instrument and matching identification strip of biological merry Emmanuel in France,the drug sensitive test was performed with K-B paper diffusion method and judged by CLSI 2009susceptibility standard.RESULTS Totally 205strains of pathogens were cultured from 516patients,there were 119(58.1%)strains of gram-negative bacteria,72(35.1%)strains of gram-positive bacteria,and 14(6.8%)strains of fungi;the Escherichia coli(13.6%),Klebsiella pneumonia(12.7%),Pseudomonas aeruginosa(11.7%)and Haemophilus influenzae(9.8%)ranked the top four species of gram-negative bacteria;the Staphylococcus aureus(22.0%)and Staphylococcus epidermidis(8.3%)were the main species of gram-positive bacteria;Candida albicans(5.4%)was the predominant species of fungi.The drug resistance rates of gram-negative bacteria to ampicillin were the highest, they were 96.4%,92.3%,100.0%,and 35.0%,respectively,and the drug resistance rate to imipenem was the lowest(0);the drug resistance rate of the gram-positive bacteria to penicillin was the highest(100.0%),and the drug resistance rates to rifampincin and vancomycin were the lowest(0).CONCLUSION It is necessary to reasonably use antibiotics for the treatment of lower respiratory tract infections in the children according to the species of pathogens causing infections.