Effects of adefovir dipivoxil combined with kushensu in lamivudine-resistant patients with chronic hepatitis B

Objective:To explore the effects of adefovir dipivoxil combined with kushensu in lamivudine-resistant patients with chronic hepatitis B. Methods:All selected cases of chronic hepatitis B were divided into two groups,adefovir dipivoxil treatment group and combination treatment group. In adefovir dipivoxil treatment group,adefovir dipivoxil was given 10 mg one time a day for 48 weeks. In combination treatment groupe,adefovir dipivoxil was given as the same, but kushensu was given 0.6 mg intravenous drip one time a day for 48 weeks. At the end of the therapy,the rates of viral response,chemical response,HBeAg negative and anti-HBe transformation were detected. Results:After 24 weeks of therapy,in adefovir dipivoxil treatment group and combination treatment group,the rates of viral response, chemical response,HBeAg negative and anti-HBe transformation was 53%,53%,15%,6% and 59%,68%,26%,12% respectively.And after 48 weeks of therapy,the rates of viral response,chemical response,HBeAg negative and anti-HBe transformation was 68%,74%,38%,21% and 85%,91%,56%,38% respectively. Conclusion:Adefovir dipivoxil is an effective treatment method for lamivudine-resistant patients with chronic hepatitis B, and the effect would be more significant by treating more long time. Also,the effect would be more significant when combination with kushensu.