The observation of curative effect of Adefovir Dipivoxil for Chronic Hepatitis B.

Objective To observe clinical effect of lamivudine and adefovir dipivoxil on the patients with chronic hepatitis B.Methods 90 patients were randomly divided into 2 groups:45 patients in each group.Group A were taken adefovir dipivoxil 10 mg once a day,for 12～24 months(the mean of 14.5 months);The group B were administrated with lamivudine 100 mg once a day.RusuIts The clinical status,the effect and the negative rate of HBV-DNA,the negative rate of HbeAg,the negative rate of HbeAg and anti-Hbe,normalization rate of ALT in each group was 64.4%、42.2%、37.8%、88.9%and 62.2%、44.4%、33.3%、62.2%,the incidence of side reaction was 2.2%,were not statistical difference between groups A and B,P0.05;and there were differences of drug-resistance between the two groups,P0.0S.Conclusion The adefovir dipivoxil had characteristics of low drug-resistance,high normalization rate and safety.