Effects and Its Mechanism of Moderately Intense Endurance Exercise and Grape Seed Proanthocyanidin on Atherosclerosis Formation in Rats Fed with High-Fat Diet

Objective:To explore the effect and its mechanism of moderately intense endurance exercise and grape seed proanthocyanidin(GSP)on atherosclerosis(AS)formation in rats fed with high-fat diet.Methods:60grown male SD rats were randomly divided into normal diet control group(Group C),high-fat diet control group(Group H),high-fat diet and placebo group(Group Hp),high-fat diet and GSP group(Group Hm),high-fat diet and moderately intensity endurance exercise group(Group Hm),high-fat diet and GSP associate with moderately intensity endurance exercise group(Group Hmg).Exclude group C,the other groups rats were fed with high-fat diet.At the same time,the groups who were fed with high-fat diet were intervened by GSP and moderately intense endurance exercise.We have observed whether the AS lesions existed in rats,analyze d AS percent plaque area,and detected serum serum Total Cholesterol(TC),Triglyceride(TG),Low Density Lipoprotein Cholesterol(LDL – C),High Density Lipoprotein Cholestrerol(HDL-C)and Superoxide Dismutase(SOD),Malondialdehyde(MDA)and Oxidative Low Density Lipoprotein(ox-LDL)indexs.Results:Serum TC,TG,LDL-C, MDA and ox-LDL levels increased significantly in rats fed with high-fat diet,and HDL-C,SOD decreased significantly.In the meanwhile,Atherosclerotic Index(AI)increased significantly,and the aortic under the sultan IV dye,the Hematoxylin-Eosin(HE)put up AS morphology lesion.But compared with Group H,the above abnormal changes for different degrees got the chain-like relief in Group Hg,Group Hm and Group Hmg.Conclusion:GSP and moderately intense endurance exercise can improve the abnorm of lipids metabolism,and enhance the organism's ability of antioxygen by increasing the activity of SOD and finaly prevent AS formation with controlling the concentration of ox-LDL,and GSP combined with moderately intense endurance exercise can contribute to express the advantages of synergistic effect.