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Quality control of Gukang Capsules

Feng Jing-qing

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Abstract

AIM To establish qualitative and quantitative methods for Gukang Capsules(Epimedii Folium,Drynariae Rhizoma).METHODS TLC was performed to identify Epimedii Folium,Drynarial Rhizoma in Gukang Capsules.HPLC was used to determine the contents of icariin and naringin.The gradient elution was performed on a SinoChrom ODS-BP column(5 μm,4.6 mm×250 mm) with acetonitrile-4% acetic acid solution as the mobile phase.The flow rate was 1.0 mL/min.The detection wavelength was set at 270 nm and 283 nm.RESULTS The spots on TLC plates were clear without interference.The calibration curve was linear within the range of 0.266~2.66 μg for icariin,and the average recovery was 99.10%(RSD was 1.27%).The calibration curve was linear within the range of 0.099-0.99 μg for naringin,and the average recovery was 99.50%(RSD was 1.45%).CONCLUSION The methods are simple,reliable,accurate,reproducible,and suitable for the quality control of Gukang Capsules.

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What this paper is about

AIM To establish qualitative and quantitative methods for Gukang Capsules(Epimedii Folium,Drynariae Rhizoma).METHODS TLC was performed to identify Epimedii Folium,Drynarial Rhizoma in Gukang Capsules.HPLC was used to determine the contents of icariin and naringin.The gradient elution was performed on a SinoChrom ODS-BP column(5 μm,4.6 mm×250 mm) with acetonitrile-4% acetic acid solution as the mobile phase.The flow rate was 1.0 mL/min.The detection wavelength was set at 270 nm and 283 nm.RESULTS The spots on TLC plates were clear without interference.The calibration curve was linear within the range of 0.266~2.66 μg for icariin,and the average recovery was 99.10%(RSD was 1.27%).The calibration curve was linear within the range of 0.099-0.99 μg for naringin,and the average recovery was 99.50%(RSD was 1.45%).CONCLUSION The methods are simple,reliable,accurate,reproducible,and suitable for the quality control of Gukang Capsules.

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Available abstract

AIM To establish qualitative and quantitative methods for Gukang Capsules(Epimedii Folium,Drynariae Rhizoma).METHODS TLC was performed to identify Epimedii Folium,Drynarial Rhizoma in Gukang Capsules.HPLC was used to determine the contents of icariin and naringin.The gradient elution was performed on a SinoChrom ODS-BP column(5 μm,4.6 mm×250 mm) with acetonitrile-4% acetic acid solution as the mobile phase.The flow rate was 1.0 mL/min.The detection wavelength was set at 270 nm and 283 nm.RESULTS The spots on TLC plates were clear without interference.The calibration curve was linear within the range of 0.266~2.66 μg for icariin,and the average recovery was 99.10%(RSD was 1.27%).The calibration curve was linear within the range of 0.099-0.99 μg for naringin,and the average recovery was 99.50%(RSD was 1.45%).CONCLUSION The methods are simple,reliable,accurate,reproducible,and suitable for the quality control of Gukang Capsules.

Key concepts: Icariin, Naringin, Chromatography, Calibration curve, Chemistry, High-performance liquid chromatography, Acetic acid, Folium of Descartes

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