The Relationship between T Cell Subsets,Expression of Costimulatory Molecules and the Immunopathy of Systemic Lupus Erythematosus

Objective To explore the relationship between T cell subsets, expression of costimulatory molecules and the immunopathy of systemic lupus erythematosus (SLE).Methods T cell subsets of peripheral blood and the expression of costimulatory molecules on the membrane surface of peripheral blood mononuclear cells in SLE patients and normal persons were detected by immunofluorescent lebeled technology and flow cytometry analysis.Results ①Compared with normal subjects, CD3 +,CD4 +,CD4 +CD28 +,CD8 +CD28 + T cell subsets were significantly decreased.The ratio of CD4/CD8 T cells was reversed; ②Significantly decresed expression of costimulatory molecule CD28 and increased expression of 4-1BB in SLE patients were observed; ③Negatived correlation was found between the ratio of CD4/CD8 T cells and the titer of ANA;On the contrary, the expression of costimulatory molecule 4-1BB was positively correlated with ANA and urine protein,while negatively correlated with CD4 +CD28 + T cell.Conclusion The changes of T cell subsets and abnormal expression of costimulatory molecules may have important affect on the pathogenesis of SLE.