The Study of Human Papillomavirus Genotyping in Cervical Cancer

Objective To investigate the clinical significance of detection on Human Papillomavirus(HPV) Genotypes in Patients with cervical cancer.Methods Flow-through hybridization and gene chip was used to detect HPV genotypes in specimens of exfoliated cells from 1169 cervical cancer patients.Results In 1 169 cases the infection rate of HPV was 91.70%(1 072/1 169),the rate of single genotype of HPV was 77.16%(902/1169),the rate of multiple genotypes of HPV was 14.54%(170/1169),The most common genotypes were HPV l6(62.10%),HPV18(10.95%),HPV58(10.52%),HPV52(7.96%),HPV33(3.93%).The infection rate of HPV18 in cervical nonsquamous cell cancer was 12.99%,which in cervical squamous cell cancer was 6.87%,HPV18 infection was more common in patients of nonsquamous cell cancer(χ2=3.994,P0.05).Conclusion The prevalence of main HPV genotypes in cervical cancer in Zhejiang province is accordant to that of Asia,and also has its own character.HPV18 is significant related with nonsquamous histology.The study can help to determine the high-risk factors and groups of cervical cancer,and may be of great value for the promotion,research and development of HPV vaccine in our region.