Effect of micronization on dissolution of Flos Lonicerae Japonicae

Objective:To study the effect of micronization on the dissolution of Chinese medical material,Flos Lonicerae Japonicae. Methods:The content of chlorogenic acid was taken as the index in identification. Thin layer chromatography was adopted to identify Flos Lonicerae Japonicae in quality and UV spectrophotometry was used to determine the content of chlorogenic acid in Flos Lonicerae Japonicae. Results:As the particle size became finer,the extractions of the effective component,chlorogenic acid in Flos Lonicerae Japonicae were increased remarkably,namely ultramicro powder(10 μm)fine powder of 160-mesh sievefine powder of 120-mesh sievefine powder of 80-mesh sievefine powder of 60-mesh sieve. The content of effective component in ultramicro power was increased by 14.4% comparing with that in the fine powder of 60-mesh sieve. Conclusion:Micronization impacts remarkably the dissolution of Flos Lonicerae Japonicae.