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EFFECT OF LOUICERA JAPONICA THUMB-CONTAINING-SERUM ON RELEASING OF NO FROM NORMAL AND LIPOPOLYSACCHARIDE INDUCED PRIMARY RATS MICROGLIA CELLS

Dong Mei

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Abstract

Objective Using a method of serum pharmacology,the effect of louicera japonica thumb on the releasing of nitric oxide(NO) from normal and lipopolysaccharide(LPS) induced primary rat microglia cells was studied.Methods By Griess and 3-(4,5-dimethyl-2thiahiazoy1)-3,5-di-phenyl-tetrazolium bromide(MTT) test,the content of NO in the primary rat microglia cells in the presence or absence of LPS(1 mg/L) for 48h was examined.Results The results showed that the containing-serum markedly inhibited the releasing of NO in the primary rat microglia cells and stimulated cells by LPS.Conclusion These results indicated that the containing-serum possesses significant fuctions such as anti-inflammatory and immune suppression.

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Objective Using a method of serum pharmacology,the effect of louicera japonica thumb on the releasing of nitric oxide(NO) from normal and lipopolysaccharide(LPS) induced primary rat microglia cells was studied.Methods By Griess and 3-(4,5-dimethyl-2thiahiazoy1)-3,5-di-phenyl-tetrazolium bromide(MTT) test,the content of NO in the primary rat microglia cells in the presence or absence of LPS(1 mg/L) for 48h was examined.Results The results showed that the containing-serum markedly inhibited the releasing of NO in the primary rat microglia cells and stimulated cells by LPS.Conclusion These results indicated that the containing-serum possesses significant fuctions such as anti-inflammatory and immune suppression.

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Available abstract

Objective Using a method of serum pharmacology,the effect of louicera japonica thumb on the releasing of nitric oxide(NO) from normal and lipopolysaccharide(LPS) induced primary rat microglia cells was studied.Methods By Griess and 3-(4,5-dimethyl-2thiahiazoy1)-3,5-di-phenyl-tetrazolium bromide(MTT) test,the content of NO in the primary rat microglia cells in the presence or absence of LPS(1 mg/L) for 48h was examined.Results The results showed that the containing-serum markedly inhibited the releasing of NO in the primary rat microglia cells and stimulated cells by LPS.Conclusion These results indicated that the containing-serum possesses significant fuctions such as anti-inflammatory and immune suppression.

Key concepts: Lipopolysaccharide, Microglia, Griess test, Nitric oxide, Chemistry, Immune system, Molecular biology, Endocrinology

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EFFECT OF LOUICERA JAPONICA THUMB-CONTAINING-SERUM ON RELEASING OF NO FROM NORMAL AND LIPOPOLYSACCHARIDE INDUCED PRIMARY RATS MICROGLIA CELLS — Research Paper | ScholarLens