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2007•Journal of Emergency in Traditional Chinese MedicineRequires access

The Inhibitory Effect of Matrine on the Proliferation of Human Gastric Cancer Cell Line NCI-N87 in Vitro

Zhong Wang

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Abstract

Objective:To investigate the inhibition of different concentrations of matrine on Proliferation of human gastric cancer cell line NCI-N87 cultured in vitro.Methods:NCI-N87 cells were treated by matrine in different concentrations and variablc durations.Cell growth and proliferation were observed by CCK-8 assay.Morphological changs of cell were observed,and cell-DNA distribution was assayed.Results:When the drug concentration was higher than 3.0mg/ml,the major effect was cell mecrosis.Matrine in the concentrations from 0.5mg/ml to 2.0mg/ml could inhibit proliferation of NCI-N87 cells as reveled by CCK-8 assay.Increase in the percentage of Gl phase cell was observed by flow cytometry.Conclusion:Matrine can inhibit the proliferation of human gastric cancer cell line NCI-N87 efficiently by affecting the cycle of cells.

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What this paper is about

Objective:To investigate the inhibition of different concentrations of matrine on Proliferation of human gastric cancer cell line NCI-N87 cultured in vitro.Methods:NCI-N87 cells were treated by matrine in different concentrations and variablc durations.Cell growth and proliferation were observed by CCK-8 assay.Morphological changs of cell were observed,and cell-DNA distribution was assayed.Results:When the drug concentration was higher than 3.0mg/ml,the major effect was cell mecrosis.Matrine in the concentrations from 0.5mg/ml to 2.0mg/ml could inhibit proliferation of NCI-N87 cells as reveled by CCK-8 assay.Increase in the percentage of Gl phase cell was observed by flow cytometry.Conclusion:Matrine can inhibit the proliferation of human gastric cancer cell line NCI-N87 efficiently by affecting the cycle of cells.

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Available abstract

Objective:To investigate the inhibition of different concentrations of matrine on Proliferation of human gastric cancer cell line NCI-N87 cultured in vitro.Methods:NCI-N87 cells were treated by matrine in different concentrations and variablc durations.Cell growth and proliferation were observed by CCK-8 assay.Morphological changs of cell were observed,and cell-DNA distribution was assayed.Results:When the drug concentration was higher than 3.0mg/ml,the major effect was cell mecrosis.Matrine in the concentrations from 0.5mg/ml to 2.0mg/ml could inhibit proliferation of NCI-N87 cells as reveled by CCK-8 assay.Increase in the percentage of Gl phase cell was observed by flow cytometry.Conclusion:Matrine can inhibit the proliferation of human gastric cancer cell line NCI-N87 efficiently by affecting the cycle of cells.

Key concepts: Matrine, Cell growth, In vitro, Cell culture, Medicine, Cell cycle, Cell, Flow cytometry

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The Inhibitory Effect of Matrine on the Proliferation of Human Gastric Cancer Cell Line NCI-N87 in Vitro — Research Paper | ScholarLens