Effects of matrine on proliferation of EC-109 cells

Objective To investigate the effect of matrine on proliferation of EC-109 cell.Methods Ec-109 cells cultivated in vitro were treated by different concentrations of matrine(0.187 5,0.375,0.75,1.5 mg/mL).And then,the changes of cell morphology and cell growth number were observed by inverted microscope and the cellulotoxic activity of matrine was detected by MTT.Results In the range of 0.187 5-1.5 mg/mL,the cells inhibition rate was 15.60%-65.69%,showing obvious inhibition of cell growth compared with the control group(P0.05).With concentration increase and time extension,the survival EC-109 cells were significantly decreased,showing obvious dose dependence.Conclusion Matrine can significantly inhibit the proliferation of EC-109 cells in vitro.