Research of Integripetal Rhodiola Herb on Learning Dysmnesia in Vascular Dementia Rats and NMDA Mechanism

Objective To study the effect of Integripetal Rhodiola herb on cognitive functions of vascular dementia rats and the mechanism of NMDA.Methods:Vascular dementia model was made through ligating double arteria carotis communis.Then protective effect of Integripetal Rhodiola herb on model nerves was observed.Morris water maze was used evaluating learning and memory in rats,immunohistochemistry was used detecting NR1 expression in NMDA,and spectrophotometry detecting absorbance of NOS in brain.Results:Cognitive ability in model group decreased more remarkably than in control group(P0.01).So Integripetal Rhodiola herb could markedly repress the expression of NR1 in NMDA,reduce the activity of NOS to stepup.Conclusion:Integripetal Rhodiola herb can antagonize neurotoxicity and protect neuron from damage of NO.