2008•Zhongguo zhongyiyao xinxi zazhiRequires access

Effects of Rhodiola Herb on Behavior and the Expression of Bcl-2 and Bax Protein in the Hippocampus of Vascular Dementia Rats

Juan Cao

Abstract

Objective To study the effects of Rhodiola herb on behavior and the expression of Bcl-2 and Bax protein in hippocamps of vascular dementia rat induced by chonic cerebral ischemia.And the protective effect of Rhodiola herb was studied.Methods VD model was formed by adopting the permanent occlusion of bilateral carotid arteries in Wistar rats to produce the forebrain ischemia.Cognitive ability of rats were studied with the Morris water maze.The expression of Bcl-2 and Bax protein in the hippocampus were determined with immunohistochemical staining.Results VD model may decrease cognitive ability(P 0.01),increase the expression of Bcl-2 and Bax protein in the hippocampus(P 0.01).Rhodiola herb alleviated cognitive ability significantly(P0.01),increased the expression of Bcl-2 protein(P0.01) and reduced the expression of Bax protein(P 0.01).Conclusion Rhodiola herb can inhibit apoptosis through regulating the expression of Bcl-2 and Bax protein in the hippocampus.Rhodiola herb may improve cognitive ability in Vascular Dementia rats.

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Key concepts: Rhodiola, Hippocampus, Vascular dementia, Morris water navigation task, Apoptosis, Herb, Immunohistochemistry, Protein expression