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STUDY ON EFFECTS OF SELENIUM ON ALCOHOLIC BODY INJURY OF RAT.

Zhu Mao-sheng

Abstract

Objective:To study the mechanism that selenium inhibited lipid peroxidation by alcohol causing in vivo.Method:To repeat ingestion alcohol in SD rats at the dose of 3g/kg weight,and fed with the dose of 0.25mg/L selenium(Se) at the same time in three months.Results:The contents of malondiadehyde(MDA) was decreased(P0.01) and the activities of glutathione peroxidase(GSH-Px),superoxide dismitase(SOD),catalase(CAT) were increased in tissue and serum between alcohol+Se and alcohol groups(P0.05).Conclusion:The selenium could inhibit the injury of over-dose alcohol to body by elevating activities of GSH-Px,SOD and CAT.

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Key concepts: Selenium, Glutathione peroxidase, Catalase, Alcohol, Chemistry, Lipid peroxidation, Ingestion, Superoxide dismutase