Study on the release rate of s-release tablets in vitro

Aim To prepare the sustained-release tablets,and evaluate the vitro release rate of the sustained-release tablets compared with the imported tablets.Method In this study,the metformin hydrochloride sustained-release tablets were formulated with hydroxypropyl methylcellulose(HPMC) and sodium carboxymethyl cellulose(CMC-Na) by wet granulation technique,and the vitro release rate of the two sustained-release tablets were studied by similarity factor.Results The accumulation vitro release rate of the reference sustained-release tablets in 1 h,6 h were 27.71%±0.97%,67.47%±1.45%,and 5.30%±2.03%,70.34%±1.17% for the imported tablets.The accumulation vitro release rate in 12h were over 85% for the two tablets.The f2 for the two tablets was 84.18±4.67.Conclusion The results showed that the metformin hydrochloride sustained-release tablets were able to maintain sustained release for 12 h;The vitro release behaviors were equivalent evaluated by similarity factor.