Clinical Significance of Plasma D-Dimeride Detection in Patients with Breast Cancer

Objective To explore the clinical significance and judge prognostic value of plasma D-dimeride detection in patients with breast cancer.Methods 149 patients with breast cancer(breast cancer group),89 patients with mammary benign tumor(benign tumor group) and 82 healthy women(healthy control group) were enrolled in the study.The level of D-dimeride,carcinoembryonic antigen(CEA),cancer antigen 15-3(CA15-3),cancer antigen 125(CA125) and acceptor of breast cancer were measured.Results The level of D-dimeride in breast cancer group was significantly higher than that of the other two groups(P0.001),while there was no statistical significance between benign tumor group and healthy control group(P0.05).The level of D-dimeride in the breast cancer patients in stages Ⅲ~Ⅳ was significantly higher than that in stagesⅠ~Ⅱ(P0.001).Plasma D-dimeride was significantly higher in patients with axillary lymph node metastasis than that in patients without axillary lymph node metastasis(P0.001).Plasma D-dimeride was significantly higher in patients with distant organ metastasis than that in patients without distant organ metastasis(P0.001).Plasma D-dimeride was correlated with CEA,CA15-3 and CA125.Conclusion The D-dimeride level is associated with clinical stages and metastasis.Clinically it is an important prognostic marker in breast cancer.