ScholarLens Back to search
2005•Zhonghua shiyan waike zazhiRequires access

Experimental study on the improved model of rat lung transplantation

Yang Bao-feng

Open publisher page 1 citations

Abstract

Objective To improve the technique of rat single lung transplantation and establish a stable animal model.Methods The SD rats served as donor and recipients.In the donor operation,the heart-lung block was flushed in situ and harvested.The left pulmonary artery and vein were anastomosed using cuff technique.Left main bronchus was reconstructed with continuous suture of prolene.The graft function was monitored by thoracic X ray and arterial blood gas analysis.Results In 26 cases of single lung transplantation in rats,the operation was successfully carried out in 23 cases and failed in 3 cases with the successful rate being 88.5%.The survival rate was 100%.Conclusion The model of rat lung transplantation was established successfully with simple operation,which provided a basis for studying lung transplantation and immunology of lung graft.

About this research paper

What this paper is about

Objective To improve the technique of rat single lung transplantation and establish a stable animal model.Methods The SD rats served as donor and recipients.In the donor operation,the heart-lung block was flushed in situ and harvested.The left pulmonary artery and vein were anastomosed using cuff technique.Left main bronchus was reconstructed with continuous suture of prolene.The graft function was monitored by thoracic X ray and arterial blood gas analysis.Results In 26 cases of single lung transplantation in rats,the operation was successfully carried out in 23 cases and failed in 3 cases with the successful rate being 88.5%.The survival rate was 100%.Conclusion The model of rat lung transplantation was established successfully with simple operation,which provided a basis for studying lung transplantation and immunology of lung graft.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To improve the technique of rat single lung transplantation and establish a stable animal model.Methods The SD rats served as donor and recipients.In the donor operation,the heart-lung block was flushed in situ and harvested.The left pulmonary artery and vein were anastomosed using cuff technique.Left main bronchus was reconstructed with continuous suture of prolene.The graft function was monitored by thoracic X ray and arterial blood gas analysis.Results In 26 cases of single lung transplantation in rats,the operation was successfully carried out in 23 cases and failed in 3 cases with the successful rate being 88.5%.The survival rate was 100%.Conclusion The model of rat lung transplantation was established successfully with simple operation,which provided a basis for studying lung transplantation and immunology of lung graft.

Key concepts: Medicine, Lung transplantation, Prolene, Transplantation, Lung, Cuff, Pulmonary vein, Surgery

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Experimental study on the improved model of rat lung transplantation — Research Paper | ScholarLens