2011•Biaoji mianyi fenxi yu linchuangRequires access
The Changes of Sputum IL-8 and TNF-α Levels in COPD Patients and Their Clinical Value
Xiao Hui Zhou
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Abstract
To investigate the changes and role of interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α) in the diagnosis and therapy of COPD,the levels of IL-8 and TNF-α in serum and sputum samples in 58 COPD cases during different therapy periods were detected by radioimmunoassay.The results showed that the sputum IL-8 and TNF-α levels in COPD patients at the attack aggressive stage were significantly higher than those in the stable stage,which were in accord with those changes in serum samples.Furthermore,the changes of IL-8 and TNF-α levels in sputum samples were earlier than the changes in serum samples.The changes of sputum IL-8 and TNF-α levels in COPD patients may play a more important role than the changes of serum samples in the diagnosis and prognosis of patients with COPD.