Application of perfusion 64-slice spiral CT in esophageal carcinoma radiotherapy

Objective: To assess the value of 64-slice spiral CT in diagnosis of esophageal carcinoma and prediction.Methods: thirty-eight cases of esophageal carcinoma proved by nasopharyngoscopy biopsy underwent 64-slice CT perfusion imaging before radiotherapy,paired samples t-test was used to analys the perfusion parameters of pre-radiation and post-radiation,38 cases were followed up for 12~18 months,with median of 15 months.The cases were divided into groups according to whether they had local recurrence or/and metastasis.The parameters of those groups before radiotherapy were assessed with independent-sample t-test. Results: Before radiotherapy,the tissue blood flow(BF),blood volume(BV),surface permeability(PS),mean transit time(MTT),peak height(PH) of 38 cases were(341.2±137.5) ml ·100 g-1·min-1,(10.4±6.8)ml·100 g-1,(28.3±17.1)ml·100 g-1·min-1,(4.3±1.8) s,(55.9±14.7)Hu.After radiation of 60~64 Gy,these parameters were(331.4±121.0)ml·100 g-1·min-1,(8.8±5.1)ml·100 g-1,(9.6±8.9)ml·100 g-1·min-1,(3.5±2.0) s,(46.6±13.5) Hu respectively on paired-samples t-test.There was significant difference in PH,PS between per and post-radiation data,while there was no statistic significant difference in other parameters.Between the group with recurrence or/and metastasis and other groups,there was no statistic difference in parameters of perfusion before radiotherapy. Conclusion: Perfusion CT can reflect the microcirculation features of esophageal carcinoma quantitatively.Peak height decreased significantly compared with that of per-radiation.It is difficult to predict recurrence or metastasis of esophageal carcinoma after radiotherapy with the perfusion parameters.