Assessment of Relationship of Early Plasma Brain Natriuretic Peptide and Left Ventricular Remodeling and Prognosis in Patients with Acute Myocardial Infarction

Objective: To investigate the relationship between early brain natriuretic peptide(BNP) levels and left ventricular remodeling and prognosis in acute myocardial infarction(AMI).Methods: Determine plasma BNP levels in patients with early AMI by radioimmunoassay;Measure left ventricular end systolic volume(ESV),left ventricular end diastolic volume(EDV),ejection fraction(EF) by echocardiography,and left ventricle through the calculated mass(LVM).Group according to left ventricular volume index: left ventricular volume increasing rate 20% was left ventricular remodeling group,or else non-reconstructed group,plasma BNP levels of the two groups were compared.Results: The recovery of left ventricular end-diastolic reconstruction group and end-systolic volume index were higher than those of non-reconstructed group(P 0.01),also higher than the acute phase left ventricular volume(P 0.01).Recon-struction of the early group was significantly higher than plasma BNP concentration reconstruction group(P 0.01),recovery is also high-er than non-reconstructed group(P 0.01).BNP concen-tration and the reconstruction of the early recovery group left ventricular volume and volume variation of the question,a positive correla-tion.Conclusion: AMI increased with early BNP is closely related to acute left ventricular remodeling and plasma BNP levels can be used as thrombolytic recanalization therapy and prognosis based on observed indi-cators.