Effect of Quercetin on proliferation of rabbit chondrocytes

Objective To observe the effect of quercetin on chondrocyte proliferation of rabbits. Methods The degenerated rabbit chondrocyte model was established with interleukin- l beta in vitro. The model cells were divided into the blank group,the model group,30μmoL / L quercetin group,60μmoL / L quercetin group and 120μmoL / L quercetin group. Chondrocyte proliferation was detected by MTT assay. Results Absorbance( OD) value in the model group was decreased( P 0. 01) compared with that in the blank group). It referred that IL- 1β can inhibits chondrocyte proliferation to establish the degenerated chondrocyte model. The differences of absorbance( OD) value among all quercetin groups and the model group were significant differences( P 0. 01). It refered that different concentration of quercetin can obviously promote the degenerated chondrocyte proliferation,the proliferation effect being positively correlated with its concentration. Conclusion Quercetin can obviously promote the chondrocyte proliferation induced by IL- 1 β in rabbits,and quercetin has the function of prevention and control of osteoarthritis.