Comparison of Lung Function and Safety of Budesonide and Prednisone in Treating COPD Secondary to Pulmonary Fibrosis

Objective: To observe lung function of patients with chronic obstructive pulmonary disease( COPD) secondary repressor and induced pulmonary fibrosis,compare the safety of the two drugs. Method:The patients with COPD secondary to pulmonary interstitial fibrosis were randomly divided into the budesonide group( Group A,34 cases) and prednisone group( Group B,36 patients). Group A were given budesonide 2mg for onec( 1 / 8h) inhalation,group B were given prednisolone intravenously,40 mg for once( 1 /q12h),compared the FEV1 / pre-juice value,Pa O2,Pa CO2 situation after treatment of 3,5,l0 days,clinical symptom scores and adverse reactions were compared either. Result: After treatment,FEV1 / pre-juice value and arterial blood gas Pa O2,Pa CO2 lower than the time of admission,at 5 days,10 days,group A of FEV1 / pre-juice value,Pa O2 were significantly higher than that in group B,the difference there was statistically significant( P 0.05). After treatment,both groups were significantly decreased the clinical symptom scores,at 10 days,the scores of group A was lower than group B,the difference was statistically significant( P0.05). There was no significant difference between the two groups of patients overall incidence of adverse events( P 0.05). Conclusion: Budesonide and prednisone can improve lung function among COPD patients with interstitial fibrosis secondary lung,but budesonide has a long-term effects in improving FEV1 /pre-juice value,Pa O2,clinical symptom scores and reduce the stress response.