Release kinetics of total alkaloids of Corydalis Decumbentis Rhizoma(rhizome of Corydalis decumbens(Thunb.)Pers.)resinates in vitro

Objective To prepare the total alkaloids of Corydalis Decumbentis Rhizoma(rhizome of Corydalis decumbens(Thunb.)Pers.) resinates and study the protopine and tetrahydropalmatine release kinetics of the drug-resinate in vitro.Methods The drug-resinates were prepared by bath method.As the target components,the protopine and tetrahydropalmatine release kinetics were investigated in different temperature(37 ℃,45 ℃)and different release media(deionized water,0.15 mol·L-1NaCl,0.6 mol·L-1NaCl,0.15 mol·L-1KCl and 0.15 mol·L-1HCl).Results The release rates of protopine and tetrahydropalmatine were increased with the increase of ionic strength of the release media and temperatures.The release rates changed with counter-ion type.Conclusions The release rates of protopine and tetrahydropalmatine of drug-resinates are correlated with ionic strength of the release media,the types of counter-ion and temperatures.